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MA.20[16]
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EORTC[17]
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French[15]
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|---|
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Recruitment years
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2000-2007
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1996-2004
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1991-1997
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|
Number of patients
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1832
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4004
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1334
|
|
Median age
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54
|
54
|
57
|
|
Node positive
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85%
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56%
|
75%
|
|
Breast surgery
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100% breast conserving
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75% breast conserving
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100% mastectomy
|
|
CHX
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91%
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85%
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61%
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|
ER/PR negative
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25%
|
16%
|
7%
|
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Unknown ER/PR status
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n.a.
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6%
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40%
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Main inclusion criteria
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N + or high risk* N0 any location
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N + or medial/central tumor
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N + or medial/central tumor
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Breast/chest wall
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Both arms: 50 Gy / 25 fx
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Both arms 50 Gy / 25 fx
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Both arms according to practice of the center
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|
Medial supraclavicular nodes
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Experimental arm: 45 Gy / 25 fx
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50 Gy / 25 fx
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All patients: dose and fractionation according to practice of the center
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|
Internal mammary nodes
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Experimental arm: 45 Gy / 25 fx
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Experimental arm: 50 Gy / 25 fx
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Experimental arm: 45 Gy / 20 fx
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- *= > = 5 cm tumor, > = 2 cm tumor, and <10 axillary nodes removed with ER-, G3, or lymph vacular invation; n.a. = not available; fx = fractions; ER = estrogene receptor; PR = progesterone receptor.
