Table 6 Univariate and multivariate Cox regression analyses for factors affecting the occurrence of numbness
| Univariate Analyses | Multivariate Analysis | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age | 0.994 | 0.978–1.012 | 0.519 | |||
| Gender | 0.906 | 0.566–1.450 | 0.681 | |||
| Volume | 0.987 | 0.970–1.005 | 0.148 | |||
| Integral dose | 0.787 | 0.594–1.044 | 0.097 | 0.789 | 0.603–1.033 | 0.085 |
| Dmean | 0.973 | 0.937–1.010 | 0.155 | 1.024 | 0.986–1.064 | 0.214 |
| Isodose | 1.106 | 1.016–1.204 | 0.021 | 1.072 | 0.978–1.176 | 0.136 |
| Dmax | 0.969 | 0.938–1.002 | 0.062 | |||
| Prescription dose | 0.977 | 0.836–1.019 | 0.281 | |||
| Re-irradiation yes/no no as reference | 4.446 | 2.667–7.412 | 0.000 | 5.814 | 3.252–10.295 | 0.000 |
| Multiple sclerosis yes/no no as reference | 0.390 | 0.167–0.908 | 0.024 | 0.196 | 0.079–0.484 | 0.000 |