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|
Variable
|
HR
|
95% CI
|
P value
|
|---|
|
Age
|
0.999
|
0.972–1.026
|
0.9433
|
|
Sex
|
1.347
|
0.570–3.180
|
0.4972
|
|
History of smoking
|
1.489
|
0.664–3.338
|
0.3336
|
|
History of alcohol use
|
1.037
|
0.524–2.052
|
0.9178
|
|
Diabetes mellitus
|
1.247
|
0.579–2.682
|
0.5728
|
|
Performance status (0–1 vs. 2–4)
|
1.608
|
0.707–3.655
|
0.2573
|
|
Pre-RT dental evaluation
|
1.280
|
0.623–2.673
|
0.5017
|
|
Pre-RT tooth extraction
|
1.469
|
0.819–2.636
|
0.1971
|
|
Post-RT tooth extraction
|
2.630
|
1.350–5.125
|
0.0045
|
|
Tumor site (OPC/OC vs. others)
|
6.667
|
2.824–15.74
|
< 0.0001
|
|
T-stage (x, 0–2 vs. 3–4)
|
0.937
|
0.497–1.768
|
0.8410
|
|
Lymph node positive
|
1.408
|
0.657–3.020
|
0.3794
|
|
Pre-RT surgery
|
1.713
|
0.960–3.056
|
0.0687
|
|
Pre-RT mandible surgery
|
3.053
|
1.356–6.875
|
0.0070
|
|
Induction chemotherapy
|
0.748
|
0.232–2.411
|
0.6267
|
|
Concurrent chemotherapy
|
2.528
|
0.997–6.411
|
0.0507
|
|
RT technique (3D-CRT vs. IMRT)
|
0.886
|
0.380–2.063
|
0.7789
|
|
Total radiation dose
|
0.976
|
0.915–1.041
|
0.4587
|
|
V60 (≤ 14% vs. > 14%)
|
6.969
|
2.745–17.700
|
< 0.0001
|
- HR, hazard ratio; CI, confidence interval; RT, radiation therapy; OPC, oropharyngeal cancer; OC, oral cancer; 3D-CRT, 3-dimensional conformal radiation therapy; IMRT, intensity-modulated radiation therapy; V60, relative volumes of the jaw exposed to 60 Gy
