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Table 1 Clinical characteristics of ES-SCLC patients based on the radiation time

From: Clinical outcomes of extensive-stage small cell lung cancer patients treated with thoracic radiotherapy at different times and fractionations

Variables    ≤ 2cycles 3-4cycles 5-6cycles  > 6 cycles p value
Age, y  < 60 20 36 46 15  
   ≥ 60 21 42 46 18 0.950
Sex Male 34 60 68 30  
  Female 7 18 24 3 0.189
ECOG PS score 0–1 38 71 85 32  
  2 3 7 7 1 0.487
Smoking index  ≥ 400 20 47 38 15  
   < 400 21 31 54 18 0.098
Metastatic organs single 16 36 33 9  
  Multiple 25 42 59 24 0.266
Number of metastases  ≤ 2 11 18 16 4  
   > 2 30 60 76 29 0.345
Brain metastasis yes 25 46 55 22  
  no 16 32 37 11 0.891
Liver metastasis yes 9 21 35 7  
  no 32 57 57 26 0.128
Bone metastasis yes 18 22 38 20  
  no 23 56 54 13 0.014
Weight loss yes 4 8 14 5  
  no 37 70 78 28 0.695
PCI yes 3 6 5 2  
  no 38 72 87 31 0.641
Radiation dose  ≤ 50 Gy 27 50 60 22  
   > 50 Gy 14 28 32 11 0.994
  1. ES-SCLC, Extensive-stage small-cell lung cancer; ECOG PS, Eastern Cooperative Oncology Group performance status; PCI, Prophylactic cranial irradiation;
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