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Table 4 Summary of the results from the fit of the two normal tissue complication probability models for xerostomia and dry eye. AUC = area under the curve. Response rate is the average of the response rates predicted by the models. OR = Odds ratio. Threshold doses refer to gEUD and \(\overline{\overline{D}}\) (for the LKB and RS models, respectively). The p value was calculated using the two sample t-test for the patient subgroups above and below the dose threshold (the null hypothesis is that the true mean difference is zero)

From: NTCP modeling and dose–volume correlations for acute xerostomia and dry eye after whole brain radiation

Parameters Response rate (%) AUC Odds ratio p value
Threshold (Gy) OR (95% CI)
LKB model
Xerostomia 34.7 0.67 20 5.6 (1.5–20.6) 0.03
Dry eye 24.1 0.57 27 2.6 (0.6–10.9) 0.09
Relative seriality model
Xerostomia 34.6 0.67 20 5.8 (1.5–23.2) 0.03
Dry eye 24.1 0.56 27 2.6 (0.6–10.9) 0.09
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