Risk factors for radiation pneumonitis in lung cancer patients with subclinical interstitial lung disease after thoracic radiation therapy

Table 5 Correlation between risk factors and RP using binary logistic regression analysis

Factors	Grade ≥ 2 RP			Grade ≥ 3 RP
Factors	Odds ratio (OR)	95% CI	p value	OR	95% CI	p value
MLD (≥ 12.0 Gy vs. < 12.0 Gy)	2.480	1.006–6.113	0.049	–	–	–
Tumor located in lower lobe	2.311	0.898–5.943	0.082	–	–	–
Chemotherapy with gemcitabine in the past	–	–	–	3.209	1.018–10.113	0.046
V5 (≥ 50%vs. < 50%)	–	–	–	3.429	1.056–11.140	0.040
Percentage of lung volume affected in subclinical ILD ≥ 25%	–	–	–	4.861	1.237–19.104	0.024

RP, radiation pneumonitis; MLD, mean lung dose; V5, percentage of lung volume receiving ≥ 5 Gy; ILD, interstitial lung disease; CI, confidence interval

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