Table 2 Treatment-related toxicities during CCRT
| Toxicities |
DP group (n = 103) |
S-1 group (n = 72) | p value |
|---|---|---|---|
| Overall toxicity ≥ 3 | 47 (45.6%) | 16 (22.2%) | 0.002 |
| Grade 3 | 31 (30.1%) | 13 (18.1%) | 0.079 |
| Grade 4 | 16 (15.5%) | 3 (4.1%) | 0.024 |
| Hematological toxicities ≥ 3 | |||
| Anemia | 7 (6.8%) | 4 (5.6%) | 0.767 |
| Leukopenia | 35 (34.0%) | 9 (12.5%) | 0.001 |
| Neutropenia | 30 (29.1%) | 7 (9.7%) | 0.002 |
| Thrombocytopenia | 6 (5.8%) | 2 (2.8%) | 0.473 |
| Non-hematological toxicities ≥ 3 | |||
| Esophagitis | 24 (23.3%) | 12 (16.7%) | 0.344 |
| Nausea/vomiting | 10 (9.7%) | 1 (1.4%) | 0.028 |
| Mucositis | 4 (3.9%) | 3 (4.1%) | 1.000 |
| Fatigue | 9 (8.7%) | 5 (6.9%) | 0.781 |
| Pneumonitis | 5 (4.9%) | 3 (4.1%) | 1.000 |