Neoadjuvant chemoradiotherapy in patients with unresectable locally advanced sigmoid colon cancer: clinical feasibility and outcome

Table 3 Univariate and multivariable Cox analysis of prognostic factors for overall survival and progression free survival in 72 patients with unresectable sigmoid colon cancer (LASCC) treated with neoadjuvant chemoradiotherapy and surgery

	Univariate analysis		Multivariable analysis
	p	HR (95% CI)	p	HR (95% CI)
Overall survival variable
R0 resection (R0 vs. non-R0)	< 0.001	0.292 (0.184–0.465)	0.973	0.937 (0.020–42.855)
pCR (pCR vs. non-pCR)	0.172	2.342 (0.690–7.946)	0.339	0.194 (0.007–5.597)
Down T stage (yes vs. non)	0.044	3.031 (1.033–8.894)	0.426	2.021 (0.358–11.419)
pN Stage group (pN0 vs. pN1)	0.037	5.234 (1.105–24.800)	0.601	2.845 (0.057-142.977)
pT Stage group (pT0-T3 vs. pT4a-4b)	0.023	2.678 (1.144–6.272)	0.634	0.659 (0.118–3.664)
Differentiation	0.001	0.062 (0.012–0.319)	0.003	36.443 (3.500–379.429)
PNI (yes vs. non)	0.011	4.138 (1.377–12.435)	0.875	1.205 (0.119–12.166)
Progress-free survival variable
R0 resection (R0 vs. non-R0)	< 0.001	0.343 (0.219–0.538)	0.232	0.091 (0.002–4.629)
pCR (pCR vs. non-pCR)	0.035	3.697 (0.865–15.806)	0.991	497,046.093 (0.000–infinity)
Down T stage (yes vs. non)	0.006	4.109 (1.490–11.333)	0.027	6.095 (1.228–30.253)
pT Stage group (pT0-T3 vs. pT4a-4b)	0.010	2.988 (1.293–6.907)	0.797	0.818 (0.177–3.786)
Differentiation	0.111	2.292 (0.827–6.356)	0.130	4.246 (0.653–27.599)
PNI (yes vs. non)	0.015	3.883 (1.300-11.597)	0.251	3.108 (0.448–21.581)

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